Expression of c-myc proto-oncogene in normal human intestinal epithelium.
نویسندگان
چکیده
منابع مشابه
The protein encoded by the human proto-oncogene c-myc.
The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human and other mammalian versions of c-myc. We fo...
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The c-kit proto-oncogene product is a member of the family of growth factor receptors with intrinsic tyrosine kinase activity. In the mouse c-kit maps to the W locus, which is known to be of central importance in hematopoiesis. Monoclonal antibody (MoAb) YB5.B8, which was raised against peripheral blood blast cells from a patient with acute myeloid leukemia (AML), was recently shown to bind to ...
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The steady state levels of c-myc mRNA have been measured in RNA samples extracted from colonoscopic biopsies of inflammatory bowel disease patients obtained at routine endoscopy sessions. Biopsies were immediately frozen in liquid nitrogen limiting the ischaemic time to less than 15 seconds, and can be stored for up to 96 hours before separation of RNA. Yields of RNA using biopsies were 0.137 (...
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The aim of the study was to assess the expression and clinical significance of C-myc proto-oncogene in the progression of cervical neoplasms. To establish the role of this proto-oncogene in uterine cervix carcinogenesis, we examined 69 tissue samples of: low grade cervical squamous intraepithelial lesions (SIL) (n=16), high grade SIL (n=11), portio vaginalis uteri (PVU) carcinoma in situ (n=11)...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 1989
ISSN: 0022-1554,1551-5044
DOI: 10.1177/37.4.2647841